Scorpion telling the Ultimate Alliance about his team]] Scorpion was part of the team of Villains sent to attack the SHIELD Helicarrier and was the first to tell the team of Heroes about the Masters of Evil. He was easily defeated soon after. Gargan somehow escaped the Helicarrier and was sent to guard the imprisoned Tyr with the Lizard. Even though he had donned a new, stronger suit he was again defeated. Some time after the Masters of Evil had been defeated, Mac bonded with the Venom symbiote. He was captured by SHIELD and Iron Man's Pro-Reg movement and was injected with experimental Nanites to keep him under control. But he wasn't seen after that at any point in the game.